Varda Shoshan-Barmatz Selected Research

Hexokinase

1/2018	Selective induction of cancer cell death by VDAC1-based peptides and their potential use in cancer therapy.
10/2017	VDAC1 at the crossroads of cell metabolism, apoptosis and cell stress.
1/2017	Voltage-Dependent Anion Channel 1 As an Emerging Drug Target for Novel Anti-Cancer Therapeutics.
11/2016	Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction.
10/2015	The mitochondrial voltage-dependent anion channel 1 in tumor cells.
1/2012	VDAC, a multi-functional mitochondrial protein as a pharmacological target.
1/2012	VDAC1: from structure to cancer therapy.
2/2009	Voltage-dependent anion channel 1-based peptides interact with hexokinase to prevent its anti-apoptotic activity.
5/2008	Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.

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Varda Shoshan-Barmatz Research Topics

Disease

34	Neoplasms (Cancer) 01/2022 - 05/2008
7	Glioblastoma (Glioblastoma Multiforme) 10/2019 - 04/2014
5	Inflammation (Inflammations) 01/2022 - 01/2018
4	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 12/2015
4	Lung Neoplasms (Lung Cancer) 09/2019 - 04/2012
3	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 08/2010
2	Diabetes Mellitus 01/2021 - 01/2020
2	Non-alcoholic Fatty Liver Disease 01/2020 - 01/2018
2	Type 2 Diabetes Mellitus (MODY) 01/2020 - 01/2019
2	Triple Negative Breast Neoplasms 09/2019 - 12/2018
2	Alzheimer Disease (Alzheimer's Disease) 07/2019 - 12/2015
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2019 - 08/2010
2	Residual Neoplasm 12/2018 - 01/2018
2	Hypoxia (Hypoxemia) 01/2018 - 04/2012
2	Ganglion Cysts (Ganglion) 08/2005 - 07/2002
1	Hemorrhage 01/2022
1	Diarrhea 01/2022
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2022
1	Weight Loss (Weight Reduction) 01/2022
1	Foreign Bodies (Foreign Body) 06/2021
1	Obesity 01/2021
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2021
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2021
1	COVID-19 01/2021
1	Myocardial Infarction 12/2020
1	Atrial Remodeling 12/2020
1	Atrial Fibrillation 12/2020
1	Disease Progression 11/2020
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 12/2019
1	Liver Cirrhosis (Hepatic Cirrhosis) 10/2019
1	Hyperglycemia 01/2019
1	Prediabetic State (Prediabetes) 01/2019
1	Leukemia 01/2018
1	Fibrosis (Cirrhosis) 01/2018
1	Carcinogenesis 01/2018
1	Fatty Liver 01/2018
1	Hepatocellular Carcinoma (Hepatoma) 01/2018
1	Liver Neoplasms (Liver Cancer) 01/2018
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 12/2017
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2017
1	Adenocarcinoma 12/2017
1	B-Cell Lymphoma (Lymphoma, B Cell) 01/2017
1	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2016

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2010
12	Peptides (Polypeptides)IBA 11/2021 - 02/2009
9	Small Interfering RNA (siRNA)IBA 04/2020 - 06/2010
9	HexokinaseIBA 01/2018 - 05/2008
8	Mitochondrial Proteins (Mitochondrial Protein)IBA 01/2022 - 01/2013
8	Voltage-Dependent Anion Channel 1IBA 01/2022 - 10/2015
8	Apoptosis Regulatory ProteinsIBA 11/2021 - 06/2009
6	Pharmaceutical PreparationsIBA 01/2021 - 10/2015
5	Transcription Factors (Transcription Factor)IBA 04/2020 - 08/2016
5	Cytochromes c (Cytochrome c)IBA 05/2017 - 05/2008
4	EnzymesIBA 04/2020 - 05/2017
4	Voltage-Dependent Anion ChannelsIBA 01/2018 - 05/2008
3	DNA (Deoxyribonucleic Acid)IBA 04/2020 - 07/2017
3	Biomarkers (Surrogate Marker)IBA 12/2017 - 04/2012
2	Phospholipids (Phosphatides)FDA LinkGeneric 11/2021 - 01/2018
2	LipidsIBA 11/2021 - 01/2018
2	AntibodiesIBA 04/2020 - 01/2016
2	RNA (Ribonucleic Acid)IBA 10/2019 - 01/2018
2	Glucose (Dextrose)FDA LinkGeneric 10/2019 - 01/2019
2	Superoxide DismutaseIBA 01/2019 - 08/2010
2	Transferrin Receptors (Transferrin Receptor)IBA 01/2018 - 05/2017
2	Protein Isoforms (Isoforms)IBA 02/2009 - 05/2008
2	Retinaldehyde (Retinal)IBA 08/2005 - 07/2002
1	AcidsIBA 01/2022
1	CytokinesIBA 01/2022
1	Dextran SulfateIBA 01/2022
1	phosphatidylethanolamineIBA 11/2021
1	Phosphatidylcholines (Phosphatidylcholine)IBA 11/2021
1	Matrix Metalloproteinases (MMPs)IBA 06/2021
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021
1	Metformin (Glucophage)FDA LinkGeneric 01/2021
1	AldosteroneIBA 12/2020
1	Silicon Dioxide (Silica)FDA LinkGeneric 11/2020
1	Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA 11/2020
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 11/2020
1	Ciliary Neurotrophic Factor (CNTF)IBA 11/2020
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 04/2020
1	ChromatinIBA 04/2020
1	S-Adenosylmethionine (Ademetionine)IBA 04/2020
1	Streptozocin (Streptozotocin)FDA Link 01/2020
1	Mitochondrial DNA (mtDNA)IBA 12/2019
1	CholesterolIBA 07/2019
1	Surface-Active Agents (Surfactants)IBA 01/2018
1	Chelating AgentsIBA 01/2018
1	CalpainIBA 01/2018
1	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl esterIBA 01/2018
1	asparaginylendopeptidase (legumain)IBA 01/2018
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018
1	Cell-Penetrating PeptidesIBA 01/2018
1	ProteomeIBA 12/2017
1	CaspasesIBA 05/2017
1	Amyloid (Amyloid Fibrils)IBA 12/2015

Therapy/Procedure

11	Therapeutics 12/2018 - 05/2009
3	Drug Therapy (Chemotherapy) 01/2017 - 04/2012
1	Glycemic Control 01/2019
1	Intravenous Injections 01/2018
1	Radiotherapy 05/2017